Central Nervous System Mediation of Growth Hormone Secretagogue in the Pig
نویسندگان
چکیده
Rapid growth in the young pig requires an episodic pattern of growth hormone (GH) secretion. We developed different neurosurgical techniques to elucidate sites within the hypothalamus, a lower part of the brain, that regulate GH release in this species. A focus of this research is administration of small brain peptide and nonpeptide hormones that acutely affect GH release to define mechanisms of action and their efficacy in augmenting growth.
منابع مشابه
Is Ghrelin Synthesized in the Central Nervous System?
Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells located within the gastric oxyntic mucosa. In addition, some studies have reported that ghrelin cou...
متن کاملGhrelin, food intake, and botanical extracts: A Review
A kind of growth hormone secretagogue (GHS), ghrelin, was first isolated from the rat stomach and plays a major role in the activation of the growth hormone secretagogue receptor 1a (GHS-R1a) resulting the release of growth hormone (GH). The preproghrelin gene is placed on chromosome 3, at locus 3p25 –2 in humans and constitutes five exons and three introns. Ghrelin is most plentifully expresse...
متن کاملGhrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
Originally thought of as a stomach-derived endocrine peptide acting via its receptors in the central nervous system to stimulate food intake and growth hormone expression, ghrelin and its receptor (growth hormone secretagogue receptor (GHS-R)) are widely expressed in a number of organ systems, including cancer cells. However, the direct functional role of ghrelin and its receptor in tumors of c...
متن کاملFrom Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation
Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and subsequent food intake. The ghrelinergic system has therefore received considerable attention as a therapeutic target to reduce appetite in obesity as well as to stimulate food intake in conditions of anorexia, malnutrition and cachexia. As the therapeutic potential of targeting this hormone becomes clear...
متن کاملThe Role of Central Nervous System and Hypothalamic-Pituitary-Gonadal (HPG) Axis Changes in the Occurrence of Polycystic Ovary Syndrome: A Narrative Review Article
Background and Objectives: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women in reproductive age. It is associated with hyperandrogenism, obesity, menstrual iregularity and infertility. There are several hypotheses regarding the metabolic, genetic, epigenetic, and environmental causes of the disease. Although the main cause of the dise...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 1998